Hexa-D-arginine TFA

Name	Furin Inhibitor II TFA
Synonyms	Hexa-D-arginine TFA Furin Inhibitor II TFA
CAS	958204-56-3

Molecular Formula	C38H76F3N25O8
Molar Mass	1068.19
In vitro study	Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic.
In vivo study	Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.

biological activity	Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values of 106 nM,580 nM and 13.2 μM for furin,PACE4 and PC1 respectively. Hexa-D-arginine TFA can block the toxicity of Pseudomonas exotoxin A and anthrax toxin in vitro and in vivo.
target	Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)
in vitro study	Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic.
in vivo study	Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.

Last Update：2024-04-09 20:45:29

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CAS: 958204-56-3
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Mobile: +86-18821248368
QQ: 495145328

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